Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients

Table 2 Baseline characteristics of spleen operation plus interferon-treated subjects and hematologic parameters pre-/post-spleen operation

Ref.	Age	Male/female	HCV genotype, n (1/2 and 3)	HCV RNA(low/high)	Child-Pugh, n (A/B/C)	Pre-spleen operation			Post-spleen operation
						Leukocyte(×109/L)	Hemoglobin(g/L)	Platelet count(×109/L)	Leukocyte(×109/L)	Hemoglobin(g/L)	Platelet count (×109/L)
Aizawa et al[17], 2013	61.0 ± 7.1	16/14	25/5	0/30	NA	3.41 ± 1.27	125 ± 22	60 ± 14	5.13 ± 1.34	122 ± 19	167 ± 51
Akahoshi et al[18], 2012	58.1 ± 7.0	54/46	80/20	12/88	61/39/0	3.19 ± 1.14	128 ± 15	56 ± 21	5.17 ± 1.34	125 ± 14	222 ± 98
Hayashi et al[11], 2006	45.4 ± 11.1	4/3	4/21	NA	5/2/0	2.20 ± 1.70	NA	32.4 ± 12.3	NA	NA	224.4 ± 74.9
Ikezawa et al[19], 2010	62.5 (51-69)	4/6	9/1	8/2	9/1/0	3.84 ± 0.36	NA	64.2 ± 6.9	5.53 ± 0.64	NA	209 ± 40.6
Ji et al[20], 2013	51.8 ± 8.0	4/9	9/4	11/2	9/4/0	2.10 ± 0.49	NA	48.2 ± 15.9	5.70 ± 1.42	NA	186.0 ± 70.6
Kedia et al[21], 2012	NA	NA	1/5	NA	NA	NA	NA	NA	NA	NA	NA
Kercher et al[22], 2004	45.4 (27-55)	7/4	NA	NA	11/0/0	NA	NA	55.4 ± 20.8	NA	NA	441.1 ± 164.8
Liang et al[23], 2008	47.6 ± 13.9	6/3	4/5	NA	6/3/0	2.10 ± 0.70	121 ± 16	36 ± 12	5.10 ± 1.20	131 ± 14	190 ± 65
Morihara et al[24], 2009	52 (36-60)	13/3	11/5	NA	7/1/2008	3.20 (1.80-5.60)	NA	44 (27-78)	5.20 (3.70-9.00)	NA	110 (79-275)
Motomura et al[25], 2012	58 ± 1	19/18	32/5	NA	NA	NA	125 ± 3	59 ± 2	NA	NA	168.7 ± NA
Shigekawa et al[26], 2011	63.3 ± 6.6	12/23	26/9	NA	10/1/2024	3.05 ± 1.05	NA	48 ± 15	4.52 ± 0.98	NA	155 ± 55
Xie et al[27], 2012	45.6 (32-65)	22/27	NA	NA	NA	NA	NA	NA	NA	NA	NA
Foruny et al[28], 2005	NA	5/3	7/1	NA	2/6/0	2.11 (1.30-0.59)	129 (101-149)	46.2 (21-70.3)	5.57 (3.51-7.05)	141 (124-152)	180.5 (113-214)
Miyake et al[29], 2008	61 (42-70)	2/8	6/4	0/10	NA	3.59 (2.62-6.33)	130 (112-151)	75 (44-115)	5.70 (2.48-8.34)	122 (111-138)	161 (113-293)
Tahara et al[30], 20112	57.5 (36-71)	12/13	13/12	0/30	25/0/0	3.55 (1.50-7.20)	134 (99-160)	70 (32-101)	5.40 (2.60-8.10)	126 (101-160)	174 (90-338)
Takahara et al[31], 2011	62 (44-72)	5/6	10/1	NA	NA	4.71 (2.95-6.33)	127 (112-151)	93 (61-117)	7.20 (2.84-11.8)	122 (111-138)	191 (113-302)
Summary		185/186	237/79	31/162	160/72/2

¹Genotype was unavailable in one patient;

²Authors compared PSE-treated patients (25) with PSE-untreated patients (23) with thrombocytopenia receiving PEG-IFN-α-2b plus RBV over the same period. Another five patients were treated with IFN-α-2b (3) or PEG-IFNα-2a (2) plus RBV. SO: Spleen operation; IFN: Interferon; NA: Not available; PSE: Partial splenic embolization.