Intestinal ischemia-reperfusion of macaques triggers a strong innate immune response

doi:10.3748/wjg.v20.i41.15327

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2014; 20(41): 15327-15334
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15327

Table 4 mRNA expression of TLRs, MD2 and inflammatory mediators in intestinal mucosa (IOD value)

Group	TLR4	TLR2	MD2	TNF-α	IL-1β
Control	0.5 ± 0.04	0.31 ± 0.05	0.77 ± 0.05	0.35 ± 0.08	0.18 ± 0.04
IIR	1.39 ± 0.06^a	1.52 ± 0.15^a	1.94 ± 0.12^a	1.48 ± 0.15^a	0.66 ± 0.08^a

n = 5 in each group,

^aP < 0.05 vs control group. Toll-like receptor 4 (TLR4) was positively correlated with the expression of interleukin (IL)-1β (r = 0.964; P < 0.01), MD2 was positively correlated with the expression of IL-1β (r = 0.951; P < 0.01), TLR4 was positively correlated with the expression of tumor necrosis factor (TNF)-α (r = 0.951; P < 0.01) and MD2 was positively correlated with the expression of TNF-α (r = 0.955; P < 0.01). IIR: Intestinal ischemia-reperfusion.

Citation: Wu H, Deng YY, Liu L, Tan QH, Wang CH, Guo MM, Xie YM, Tang CW. Intestinal ischemia-reperfusion of macaques triggers a strong innate immune response. World J Gastroenterol 2014; 20(41): 15327-15334
URL: https://www.wjgnet.com/1007-9327/full/v20/i41/15327.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i41.15327