MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease

Table 2 miRs deregulated in human non-alcoholic fatty liver disease

Ref.	miR	miR regulation	Source	Phenotype
[74]	miR-34a miR-122 miR-21 miR-451	Up-regulation	Blood	Only miR-122 is correlated with the severity of liver steatosis
[75]	miR-122 miR-34a miR-16	Up-regulation	Blood	Positive correlation with fibrosis, inflammation and hepatic steatosis
[77]	miR-122 miR-122	Up-regulation Down-regulation	Blood/liver	From mild to severe hepatosteatosis End-stage liver fibrosis
[79]	miR-15b	Up-regulation	Blood	Positive correlation with NAFLD parameters
[80]	miR-34a miR-146 miR-122	Up-regulation Down-regulation	Liver Liver	Association between NASH and altered hepatic miRNA expression

NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis.