Primary prevention of colorectal cancer: Myth or reality?

Table 2 Drugs and colorectal cancer prevention

Role on CRC prevention	Evaluated in randomized clinical trails	Recommendation for general population	Recommendation for high risk population
Aspirin	Logan et al[34], 2008 Baron et al[61], 2003 Sandler et al[62], 2003 Benamouzig et al[63], 2011 Rothwell et al[65], 2010	No	Aspirin supplementation Dose: 80-1200 mg/d
NSAIDs	Arber et al[69], 2006 Baron et al[70], 2006 Bertagnolli et al[71], 2006	No	No, due to toxicity profile
Antioxidants	Lippman et al[76], 2009 Greenberg et al[77], 1994	No	No
Statins	Pedersen et al[80], 1996 Sacks et al[81], 1996 Emberson et al[82], 2012	No	No
Bisphosphonates	No	No	No
Postmenopausal hormonal therapy	Chlebowski et al[93], 2004	No	No, due to toxicity profile

CRC: Colorectal cancer; NSAIDs: Nonsteroidal antiinflammatory drugs.