Safety of hepatectomy for elderly patients with hepatocellular carcinoma

Table 3 Characteristics of elderly hepatocellular carcinoma patients

Ref.	Year	Country	Age	Number of patients		Sex (male) (%)		HBV (%)		HCV (%)		Child-Pugh (B) (%)		Alb (g/dL)		ICG-R15 (%)
				Y	E	Y	E	Y	E	Y	E	Y	E	Y	E	Y	E
Takenaka et al[9]	1994	Japan	70	229	39	81	69	18	5	59	881	24	13	NA	NA	17.4	18.7
Yamamoto et al[62]	1997	Japan	70	40	7	87.5	71.4	10	29	77	71	NA	NA	3.9	4.0	13.6	11.2
Poon et al[10]	1999	China	70	299	31	86	67.71	85.9	51.6	NA	NA	4.7	3.2	4.1	4.1	12.6	14.0
Wu et al[23]	1999	Taiwan	80	239	21	79.5	90.5	58.5	28.61	NA	NA	18.8	23.8	NA	NA	14.2	17.71
Hanazaki et al[11]	2001	Japan	70	283	103	78.4	68.9	23.7	18.4	40.7	55.41	20.1	26.2	3.7	3.7	21.0	21.0
Yeh et al[12]	2004	Taiwan	70	398	34	77.9	79.4	74	25.81	31.8	63.21	23.6	33.3	3.8	3.6	13.3	22.6
Ferrero et al[13]	2005	Italy	70	177	64	81.9	73.4	21.4	10.9	38.9	60.91	22.0	15.6	3.7	3.6	7.2	9.3
Zhou et al[61]	2006	China	65	125	54	85.6	88.9	84.8	59.31	NA	NA	4.8	14.81	NA	NA	NA	NA
Kondo et al[14]	2008	Japan	70	210	109	75.7	72.4	41	11.91	45.7	54.1	6.1	9.2	NA	NA	NA	NA
Kaibori et al[15]	2009	Japan	70	333	155	80.7	76.8	20.1	9.71	693	71.6	9.3	10.3	3.6	3.71	18.7	19.8
Oishi et al[16]	2009	Japan	75	502	64	76	75	24	21	66	70	15.0	8.0	3.8	3.7	17.7	18.7
Huang et al[33]	2009	China	70	268	67	82.8	86.6	88.8	65.71	1.1	7.51	4.1	6.0	4.1	4.0	NA	NA
Mirici-Cappa et al[34]	2010	Italy	70	142	43	81.7	74.4	15	7.1	47.1	57.1	31.3	27.4	NA	NA	NA	NA
Tsujita et al[17]	2010	Japan	75	77	23	67.5	73.9	22	01	65	911	4.0	0.0	4.0	4.0	18.0	19.0
Portolani et al[35]	2011	Italy	70	276	175	82.2	72	30.8	17.11	31.9	45.11	8.3	6.9	NA	NA	NA	NA
Yamada et al[24]	2012	Japan	80	267	11	77	55	27	36	58	56	8.0	22.0	3.7	3.31	17.6	19.4
Tsujita et al[25]	2012	Japan	80	385	23	65.7	65.2	23.1	8.7	70.6	87	31.7	21.7	3.9	4.0	17.0	16.5
Nishikawa et al[19]	2013	Japan	75	206	92	78.1	66.31	17.5	4.31	56.3	66.31	3.9	2.2	4.0	3.8	13.9	14.6
Hirokawa et al[59]	2013	Japan	70	120	100	82	691	NA	NA	50	681	18.0	12.0	NA	NA	14.3	15.1
Ide et al[20]	2013	Japan	75	192	64	82	67	22	13	65	69	13.0	11.0	3.9	3.9	15.7	19.1
Ueno et al[21]	2013	Japan	75	186	66	81	651	20	21	55	56	9.0	9.0	4.0	3.91	13.0	14.01
Taniai et al[64]	2013	Japan	75	353	63	77	62	NA	NA	NA	NA	24.0	11.0	NA	NA	19.1	15.0
Wang et al[63]	2014	China	70	152	56	79	71	98.7	96.5	1.3	3.6	20.0	14.0	3.9	3.9	NA	NA

¹Represents significant difference. Y: Younger patients; E: Elderly patients; Alb: Albumin; ICG: Indocyanine–green retention rate at 15 min; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NA: Not available.