Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells

Figure 1 Oridonin-mediated hallmark changes in BxPC-3 cells. A: BxPC-3 cells were treated with 0.1% dimethyl sulfoxide (DMSO) or with 0.1% DMSO containing various concentrations of oridonin. The percentage of inhibition in each sample was determined using an MTT assay. Cytotoxicity is expressed as the percentage of cell inhibition compared with the control (DMSO only). Data are expressed as mean ± SD. ^bP < 0.01 vs the control treatment; B: Western blot analysis of the effect of oridonin treatment on the target genes of survivin, vascular endothelial growth factor (VEGF), and matrix metallopeptidase 2 (MMP-2) in BxPC-3 cells. The BxPC-3 cells were treated with 0, 8, 16, or 32 μg/mL oridonin for 24 h. Three independent experiments were performed, and a representative result is shown.