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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 28, 2014; 20(40): 14747-14759
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14747
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14747
Figure 5 Pro- and anti-tumorigenic roles of osteonectin in pancreatic cancer development and progression.
Osteonectin (ON) is a multifaceted protein with controversial functions of its structural domains. ON is anti-tumorigenic and inhibits proliferation, migration, colony and xenograft formation as well as invasiveness. Facilitation of pericyte migration by ON contributes to inhibition of tumor spread. However, ON is also pro-tumorigenic and induces invasiveness.
- Citation: Kaleağasıoğlu F, Berger MR. SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer. World J Gastroenterol 2014; 20(40): 14747-14759
- URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14747.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14747