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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 28, 2014; 20(40): 14747-14759
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14747
Figure 5
Figure 5 Pro- and anti-tumorigenic roles of osteonectin in pancreatic cancer development and progression. Osteonectin (ON) is a multifaceted protein with controversial functions of its structural domains. ON is anti-tumorigenic and inhibits proliferation, migration, colony and xenograft formation as well as invasiveness. Facilitation of pericyte migration by ON contributes to inhibition of tumor spread. However, ON is also pro-tumorigenic and induces invasiveness.