SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer

Figure 2 Structural domains of osteopontin. Purple circles: Matrix binding domains; pink hexagons: Calcium binding sites; Red pentagon: Heparin binding site. There are three integrin binding sequences: (1) Arginine-glycine-aspartic acid (RGD); (2) Serine-valine-valine-tyrosine-glutamate-leucine-arginine (SVVYGLR); and (3) ELVTDFPTDLPAT. MMP cleavage sites (G¹⁶⁶-L¹⁶⁷; A²⁰¹-Y²⁰²; D²¹⁰-L²¹¹) are shown by red arrows. The thrombin cleavage site (R¹⁶⁸-S¹⁶⁹) is shown by blue arrow.