MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines

doi:10.3748/wjg.v20.i40.14904

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 40

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9229)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

569

WORD

230

HTML

5297

Figures (1-1)

271

Tables (1-3)

222

Sum=6589

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1294

Download

1346

Sum=2640

Oct 28, 2014 (publication date) through Jan 21, 2025

Times Cited of This Article

Times Cited (61)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Research Report

World J Gastroenterol. Oct 28, 2014; 20(40): 14904-14912
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14904

Table 3 Target gene expression of potential target genes

	MicroRNA		Target
	Dysregulated miRNA	Up-/down regulation	mRNA target	Up-/down regulation	X-fold (P-value)
5-FU resistant EAC	miR-192-5p	↓	TYMS	↑	+2.30 (< 0.001)
	miR-378a-3p	↓	CBL-B	↑	+1.93 (0.003)
	miR-192-5p	↓	ABCC3	↑	+1.30 (0.008)
	miR-27b-3p	↑	KRAS	↓	-1.24 (0.036)
	miR-193b-3p	↑	KRAS	↓	-1.24 (0.036)
5-FU resistant ESCC	miR-18a-3p	↓	KRAS	↑	+1.60 (0.036)
5-FU resistant ESCC	miR-125a-5p	↓	ERBB2	↑	+1.40 (0.026)

Summary of gene expression analysis for potential target genes, regulated in a direction consistent with negative posttranscriptional control of target gene expression via the respective miRNA (presented in the first column). ↓: Downregulation of the miRNA or mRNA. ↑: Upregulation of the miRNA or mRNA. Fold changes for target gene expression are provided with P-values in brackets. FU: 5-FU resistant cells; EAC: Esophageal adenocarcinoma cells; ESCC: Esophageal squamous cell carcinoma cells.

Citation: Hummel R, Sie C, Watson DI, Wang T, Ansar A, Michael MZ, Hoek MVD, Haier J, Hussey DJ. MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines. World J Gastroenterol 2014; 20(40): 14904-14912
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14904.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14904