MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines

doi:10.3748/wjg.v20.i40.14904

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2014; 20(40): 14904-14912
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14904

Table 3 Target gene expression of potential target genes

	MicroRNA		Target
	Dysregulated miRNA	Up-/down regulation	mRNA target	Up-/down regulation	X-fold (P-value)
5-FU resistant EAC	miR-192-5p	↓	TYMS	↑	+2.30 (< 0.001)
	miR-378a-3p	↓	CBL-B	↑	+1.93 (0.003)
	miR-192-5p	↓	ABCC3	↑	+1.30 (0.008)
	miR-27b-3p	↑	KRAS	↓	-1.24 (0.036)
	miR-193b-3p	↑	KRAS	↓	-1.24 (0.036)
5-FU resistant ESCC	miR-18a-3p	↓	KRAS	↑	+1.60 (0.036)
5-FU resistant ESCC	miR-125a-5p	↓	ERBB2	↑	+1.40 (0.026)

Summary of gene expression analysis for potential target genes, regulated in a direction consistent with negative posttranscriptional control of target gene expression via the respective miRNA (presented in the first column). ↓: Downregulation of the miRNA or mRNA. ↑: Upregulation of the miRNA or mRNA. Fold changes for target gene expression are provided with P-values in brackets. FU: 5-FU resistant cells; EAC: Esophageal adenocarcinoma cells; ESCC: Esophageal squamous cell carcinoma cells.

Citation: Hummel R, Sie C, Watson DI, Wang T, Ansar A, Michael MZ, Hoek MVD, Haier J, Hussey DJ. MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines. World J Gastroenterol 2014; 20(40): 14904-14912
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14904.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14904