Adjuvant therapy in pancreatic cancer

doi:10.3748/wjg.v20.i40.14733

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Oct 28, 2014 (publication date) through Aug 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2014; 20(40): 14733-14746
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14733

Table 5 Current phase III trials investigating adjuvant therapy in pancreatic cancer

Trial number	Co-ordinating country	First enrolment	Target sample size (n)	Adjuvant treatment arms	Primary outcome	Secondary outcomes (clinical only)
ISRCTN96397434	United Kingdom	2008	1396	(I) Gemcitabine	OS	Toxicity
(ESPAC-4)				(II) Gemcitabine plus capecitabine		Quality of life
						OS at 2 and 5 yr
						DFS at 5 yr
DRKS00000247	Germany	2008	436	(I) Gemcitabine	DFS	OS
(CONKO-005)				(II) Gemcitabine plus erlotinib		Toxicity
NCT01013649	United States	2009	950	(I) Gemcitabine	OS	DFS
(RTOG 0848)				(II) Gemcitabine plus erlotinib		Toxicity
				If DFS at end of treatment (I) or (II), further randomisation to:		Correlation between baseline fatigue and survival
				(III) A further course of (I) or (II) as previously received plus Capcitabine CRT
				(IV) A further course of (I) or (II) as previously received plus 5-FU CRT
NCT01072981	United States	2010	722	Gemcitabine +/- 5-FU CRT +/- HyperAcute^®-Pancreas (algenpantucel-L) immunotherapy	OS
NCT01526135	France/Canada	2012	490	(I) Gemcitabine	DFS at 3 yr	OS at 3 yr
				(II) mFolfirinox (5-FU, folinic acid, irinotecan, oxaliplatin)
NCT01077427	Germany	2012	336	(I) Gemcitabine	DFS	OS
				(II) Gemcitabine plus cisplatin plus regional hyperthermia
NCT01964430	United States	Not yet active	-	(I) Gemcitaine	DFS/OS
				(II) Gemcitabine plus nab-paclitaxel

OS: Overall survival; DFS: Disease-free survival; CRT: Chemoradiotherapy; 5-FU: 5-flurouracil.

Citation: Jones OP, Melling JD, Ghaneh P. Adjuvant therapy in pancreatic cancer. World J Gastroenterol 2014; 20(40): 14733-14746
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14733.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14733