Non-invasive diagnosis of alcoholic liver disease

Table 5 Serum fibrosis markers in alcoholic liver disease

Serum marker	n	Outcome	Ref.
PIIINP	44	Correlation of PIIINP with fibrosis, but not inflammation or steatosis; PIIINP also positively correlated with ALP and GGT	Gabrielli et al[106], 1989
ApoA1	482	Correlation with fibrosis (r = -0.70; P ≤ 0.001)	Bedossa et al[107], 1989
PGA (GGT PT ApoA1) PT	624	AUROC not significant	Poynard et al[108], 1991
PIIINP, Laminin	44	PIIINP, PIIINP-Fab and laminin measured by RIA were 21 ± 19 μg/L, 90 ± 42 μg/L and 2.5 ± 0.8 U/mL in alcoholic cirrhosis	Lotterer et al[109], 1992
PIIINP Type I col	69	Correlation PIIINP and score of alcoholic hepatitis (r = 0.60, P ≤ 0.0001) Correlation type I collagen and fibrosis score (r = 0.34, P ≤ 0.001)	Trinchet et al[110], 1992
TIMP1, PIIINP	44	Correlation TIMP1 and fibrosis (r = 0.70, P < 0.001 AUROC 0.96 ± 0.03)	Li et al[111], 1994
CDT	74	Sensitivity of CDT for alcohol consumption 57% with 100% specificity	Seitz et al[112], 1995
HA, PIIINP	45	AUROC for PIIINP 0.867 ± 0.054	Pares et al[55], 1996
7S-IV col, TH-IV col, Laminin, TIMP	58	TH-IV concentration as best marker to distinguish ALD from non-ALD; good correlation between hepatic type V collagen and serum TH-IV, but not 7S-IV collagen; TIMP, may be useful in evaluating the degree of hepatic fibrosis	Tsutsumi et al[113], 1996
HA PT	160	Accuracy for cirrhosis diagnosis from 89.5% to 95%	Oberti et al[114], 1997
YKL-40	20	YKL-40 was significantly increased in patients with alcoholic cirrhosis (median, 523 μg/L; P < 0.001)	Johansen et al[115], 1997
YKL-40, HA, PGA, Tran index	146	Threshold of 330 μg/L gave sensitivity of 50.8% with specificity 88.5% Correlation HA and prothrombin index	Tran et al[116,117], 2000
HA	70	Significant correlation (P < 0.01) between HA and albumin, platelets and bilirubin, but not with ALT	Plevris et al[118], 2000
TPS	77	TPS correlated significantly with liver cell necrosis and Mallory's hyaline degeneration	González-Quintela et al[119], 2000
Laminin Type-IV col	80	Cut-off for Laminin 4.1 UI/mL gave 90% sensitivity, 77% specificity, cut-off for CIV 150 ng/mL gave 89% sensitivity 77% specificity	Castera et al[120], 2000
Type-VI col	61	CVI and CXIV as sensitive marker in fibrosis progression in alcoholics	Stickel et al[121], 2001
Type-XIV col	13
PT	243	Correlation PT and fibrosis score; r = -0.70, P < 0.0001	Croquet et al[122], 2002
YKL-40, PIIINP	370	Serum levels of YKL-40 and PIIINP are elevated in alcoholic patients; related to fibrosis	Nøjgaard et al[123], 2003
HA	87	Correlation HA and histological stage of ALD (r = 0.54, P < 0.0001); AUROC for HA and fibrosis 0.76	Stickel et al[124], 2003
ELF panel	64	AUROC 0.94 ± 0.056	Rosenberg et al[125], 2004

ALD: Alcoholic liver disease.