Non-invasive assessment of liver fibrosis in chronic hepatitis B

Table 5 Performances of Fibrotest for the diagnosis of fibrosis (F2-F4) and assessment of prognosis in chronic hepatitis B

Outcome	Patients (n)	Cut-off (kPa)	Sn	Sp	LR+	LR-	AUROC (95%CI)	Ref
Significant fibrosis F ≥ 2	194	0.32	79.3%	93.3%	11.8	0.2	0.90 (0.84-0.97)	[74]
	254	0.48	54.2%	83.3%	3.3	0.6	0.69 (0.63-0.75)	[72]
Cirrhosis F4	194	0.68	80.0%	84.0%	5	0.2	0.87 (0.82-0.92)	[74]
	254	0.75	42.1%	91.4%	4.9	0.6	0.68 (0.63-0.73)	[72]
Prediction of 5-yr survival	600	≤ 0.73> 0.85	-	-	-	-	0.82 (0.71-0.89)	[51]

Sn: Sensitivity; Sp: Specificity; LR^-: Negative likelihood ratio; LR⁺: Positive likelihood ratio; AUROC: Area under receiver operating characteristic.