Non-invasive assessment of liver fibrosis in chronic hepatitis B

Table 3 Transient elastography performance for the detection of portal hypertension and esophageal varices in various settings including chronic hepatitis B

Ref.	Prevalence	Aetiology	Patients (n)	Cut off (kPa)	Sn	Sp	LR-	LR+	AUROC
	Significant PH1
Bureau et al[91]	51%	Mixed	150	21.0	90%	93%	0.10	12.8	0.94 (0.90-0.98)
Robic et al[38]	51%	Mixed	100	21.1	100%	65%	0.00	2.8	0.84 (0.76-0.82)
	EV
Kazemi et al[40]	41%	Mixed	165	13.919	95% 91%	43% 60%	0.13 0.14	1.7 2.3	0.83 (0.78-0.90)0.84 (0.76-0.89)
Bureau et al[91]	72%48%2	Mixed	150	21.1 29.3	84% 81%	71% 61%	0.22 0.31	2.9 2.1	0.85 (0.77-0.82)0.76 (0.67-0.85)
Nguyen-Khac et al[92]	22%	Mixed	183	48	73%	73%	0.37	2.7	0.76 (0.69-0.82)
Kim et al[42]	32%2	HBV	280	5.53	94%	94%	0.06	15.7	0.95 (0.93-0.97)
Sporea et al[39]	35%2	Mixed	1000	31	83%	62%	0.27	2.2	0.78
Chen et al[41]	80%2	HBV	222	17.1	90%	44%	0.22	1.6	0.73 (0.66-0.80)
Wang et al[93]	38%10%2	HBV	126	1221	67% 77%	77% 87%	0.43 0.27	2.89 5.79	0.73 (0.65-0.80)0.86 (0.79-0.91)

¹Hepatic vein pressure gradient > 12 mmHg;

²Large/high risk esophageal varices;

³LSPS. Sn: Sensitivity; Sp: Specificity; LR^-: Negative likelihood ratio; LR⁺: Positive likelihood ratio; AUROC: Area under receiver operating characteristic; HBV: Hepatitis B virus.