Non-invasive assessment of liver fibrosis in chronic hepatitis B

Table 1 Transient elastography performance for the diagnosis of significant fibrosis (F ≥ 2) in chronic hepatitis B

Ref.	Patients (n)	Cut-off (kPa)	Sn	Sp	LR-	LR+	AUROC (95%CI)
Oliveri et al[21]	188	7.5	93%	88%	0.07	8.2	0.96 (0.94-0.99)
Marcellin et al[89]	173	7.2	70%	83%	0.36	2.6	0.81 (0.73-0.86)
Chan et al[34]	161	8.4	84%	76%	0.20	3.5	0.87 (0.82-0.93)
Degos et al[90]	284	5.2	89%	38%	0.28	1.4	-
Viganò et al[25]	217	8.7	64%	92%	0.40	7.5	-
Verveer et al[27]	241	6.0	-	-	-	-	0.85
Cardoso et al[26]	202	7.2	74%	88%	0.30	6.2	0.86

Sn: Sensitivity; Sp: Specificity; LR^-: Negative likelihood ratio; LR⁺: Positive likelihood ratio; AUROC: Area under receiver operating characteristic.