Clinical management of advanced gastric cancer: The role of new molecular drugs

doi:10.3748/wjg.v20.i40.14537

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Oct 28, 2014 (publication date) through Nov 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2014; 20(40): 14537-14558
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14537

Table 4 Clinical trials with anti-human epidermal growth factor receptor 2 agents for advanced gastric cancer and gastro-esophageal junction cancer

Trial	Phase	Setting	Regimen	Patients (n)	OS (mo)	TTP/PFS (mo)
ToGa Trial[122], 2010	III	1^st line	CF/X + T	594	13.8	6.7
			CF/X		11.1	5.5
NCT00680901[129], 2013	III	1^st line	OX + Lap	487	12.2	6.0
			OX		10.5	5.4
NCT00486954[130], 2010	III	2^nd line	PTX + Lap	430	11.0	5.6
			PTX		8.9	4.2

C: Cisplatin; F: 5-fluorouracil; X: Capecitabine; T: Trastuzumab; O: Oxaliplatin; Lap: Lapatinib; PTX: Paclitaxel; OS: Overall survival; TTP/PFS: Time to progression/progression free survival.

Citation: Vita FD, Martino ND, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, Auricchio A, Galizia G, Ciardiello F, Orditura M. Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroenterol 2014; 20(40): 14537-14558
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14537.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14537