Clinical management of advanced gastric cancer: The role of new molecular drugs

doi:10.3748/wjg.v20.i40.14537

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 28, 2014; 20(40): 14537-14558
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14537

Table 1 Phase II/III trials with anti vascular-endothelial growth factor agents for advanced gastric cancer and gastro-esophageal junction cancers

Trial	Phase	Setting	Regimen	Patients (n)	RR	OS (mo)	TTP/PFS (mo)
NCT00084604[49], 2006	II	1^st line	Iri + C + Bev	47	65%	12.3	8.3
NCT00217581[50], 2010	II	1^st line	DOCOX + Bev	38	59%	11.1	6.6¹
	II	1^st line	DOCOX + Bev	38	59%	11.1	6.6¹
AVAGAST[51,54], 2010	III	1^st line	XC + Bev	387	46%	12.1	6.7
	III	1^st line	XC + Placebo	387	37.4%	10.1	5.3
ST03[55], 2012	II/III	Perioperative	ECX-B	200	-	-	-
	II/III	Perioperative	ECX-B	200	-	-	-
REGARD[58], 2012	III	2^nd line	Ram + BSC	235	-	5.2	2.1¹
	III	2^nd line	BSC	117	-	3.8	1.7¹
RAINBOW[60], 2014	III	2^nd line	PTX + Ram	665	28%	9.6	4.4
	III	2^nd line	PTX + placebo	665	28%	9.6	4.4
ECOG 5203[63], 2010	II	1^st line	TXT + C + Sor	44	39%	13.6	5.8
	II	1^st line	TXT + C + Sor	44	39%	13.6	5.8
NCT01262482[64], 2012	II	2^nd line	Sor + O	40	-	6.5	3.0¹
	II	2^nd line	Sor + O	40	-	6.5	3.0¹
NCT00411151[67], 2011	II	2^nd line	Sun	52	3.9%	5.81	1.28¹
	II	2^nd line	Sun	52	3.9%	5.81	1.28¹
NCT00226811[68], 2011	II	2^nd line	Sun	78	2.6%	6.8	2.3
	II	2^nd line	Sun	78	2.6%	6.8	2.3
NCT00970138[73], 2011	II	3^rd line	A: Placebo		-	2.5	1.4¹
			B: Apa (850 mg)		-	4.83	3.67¹
			C: Apa (425 mg bid)	144		4.27	3.2¹
NCT01512745[74], 2012	III	3^rd line	Apa	-	-	-	-
NCT01512745[74], 2012	III	3^rd line	Placebo	-	-	-	-
TEL0805 trial[75], 2011	II	1^st line	XC + Tel	39	6.7%	-	-

¹Progression free survival (PFS). Iri: Irinotecan; Cis: Cisplatin; Bev: Bevacizumab; X: Capecitabine; C: Cisplatin; E: Epirubicin; Ram: Ramucirumab; PTX: Paclitaxel; Sor: Sorafenib; Sun: Sunitinib; Apa: Apatinib; Tel: Telantinib; DOCOX: Docetaxel plus oxaliplatin; O: Oxaliplatin; TXT: Docetaxel; BSC: Best supportive care; RR: Response rate; OS: Overall survival; TTP/PFS: Time to progression/progression free survival.

Citation: Vita FD, Martino ND, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, Auricchio A, Galizia G, Ciardiello F, Orditura M. Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroenterol 2014; 20(40): 14537-14558
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14537.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14537