Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives

doi:10.3748/wjg.v20.i4.923

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Jan 28, 2014 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923

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Figure 12 Origin of cancer stem cells and tumor heterogeneity. It has been hypothesized that CSCs may derive from transformation of quiescent, normal stem cells (left) or could result from the de-differentiation of more mature cells which might re-acquire the capability of self-renewal. Other mutations might occur following transformation in both cases. SC: Stem cell; PC: Progenitor cell; DC: Differentiated cell; C: Cancer; N: Normal; CSCs: Cancer stem cells.

Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923