Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives

doi:10.3748/wjg.v20.i4.923

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Jan 28, 2014 (publication date) through Dec 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923

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Figure 11 Schematic representation of epithelial cell adhesion molecule activation. Cleavage of full length epithelial cell adhesion molecule (EpCAM) generates EpEx (extracellular domain of EPCAM) and EpICD (EpCAM Intracellular Domain) fragments. EpICD binds the scaffold protein FHL2 and joins to the transcriptional regulators β-catenin and, within the nucleus, interacts with LEF, binds to DNA and induces gene activation.

Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923