Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives

doi:10.3748/wjg.v20.i4.923

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Jan 28, 2014 (publication date) through Dec 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923

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Figure 10 Schematic representation of CD44 sequential proteolytic processing. CD44 undergoes sequential proteolytic cleavages in the ectodomain and intramembranous domain. Cleavage of CD44 ectodomain generates soluble CD44 that regulates cell attachment and migration and induces the intramembranous domain cleavage, releasing the intracellular domain of CD44 (CD44-ICD). CD44-ICD translocates to the nucleus, where it activates gene transcription, including CD44 itself, via binding to TPA-responsive elements (TRE). MMP: matrix metalloproteinase.

Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923