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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923
Figure 8 Potential molecular pathways associated with CD133.
The phosphorylation of the tyrosine 828 is involved in the binding to p85 (PI3K regulatory subunit) and in the subsequent activation of PI3K/Akt pathway, which, finally, promotes the self-renewal and tumor formation of CSCs. CSCs: Cancer stem cells.
- Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
- URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923