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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923
Table 3 Prognostic value of CD44
| Marker | Prognostic value | Ref. |
| CD44 | Association of CD44 downregulation with a lower metastatic potential of CRC cells | [61] |
| Association of CD44 downregulation with a higher metastatic and migratory potential of CRC cells | [62] | |
| Association with a reduced survival | [63] | |
| Correlation of CD44 loss with a higher tumor aggressiveness | [64] | |
| Relation with CRC cells proliferation but not with patients outcome | [65] | |
| Association with lymph node involvement and invasion depth | [66] | |
| Unfavorable prognostic factor for overall survival in advanced CRC | [66] | |
| Correlation of CD44 loss with advanced tumor stage, vascular invasion, lymph node involvement and infiltrating tumor border | [67] | |
| Association of CD44 loss in the lesion invasive front with adverse outcome of CRC patients | [67] |
- Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
- URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923