Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives

doi:10.3748/wjg.v20.i4.923

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2014; 20(4): 923-942
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.923

Table 2 Prognostic value of CD133

Marker	Prognostic value	Ref.
CD133	Worse outcome and higher risk of metastasis	[32]
	Independent prognostic marker for overall survival	[33]
	Association with CSC resistance to 5FU-based chemotherapy in CRC	[34]
	Association with resistance to conventional radiotherapy in CRC	[35]
	Prediction of distant recurrences after chemoradiotherapy in colon cancer patients	[35]
	High tumorigenicity of CD133⁺ CRC cells compared to CD133^- cells due to their interaction with CAFs by paracrine signaling axis of CXCR4-SDF1	[36]
	Risk factor for poor overall survival in stage II and III in colon cancer patients	[37]
	Relationship with K-Ras and B-Raf mutations in CRC patients	[38]

CSC: Cancer stem cell; CRC: Colorectal cancer.

Citation: Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
URL: https://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i4.923