How to select the optimal treatment for first line metastatic colorectal cancer

Table 1 Prognostic scores/health assessments

Score	Risk category	Factors
“Kohne” score[13]	Low risk	ECOG 0/1 and only one tumour site
	Intermediate risk	ECOG 0/1, ALP < 300 U/L and more than one tumour site or ECOG > 1 and WBC < 1 × 1010/L and only one tumour site
	High risk	ECOG 0/1 and more than one tumour site and ALP ≥ 300 U/L or ECOG > 1 and more than one tumour site or ECOG > 1 and WBC > 1 × 1010/L
FOCUS 2[15]	Comprehensive health assessment at baseline limited health Assessment during course of treatment (excluding MMSE and CCI)	Weight change Timed 20 metre walk MMSE CCI Patient completed questionnaire (social activity, physical fitness, symptoms, overall quality of life and depression)

ECOG: Eastern collaborative oncology group performance status; ALP: Alkaline phosphatase; WBC: White blood cells; MMSE: Mini mental state examination; CCI: Charlson comorbidity index.