Evolving treatment strategies for colorectal cancer: A critical review of current therapeutic options

Table 4 Locoregional recurrence in patients with complete clinical response who did not proceed to rectal resection n (%)

Ref.	No. of patients	T2	Radiotherapy	Chemotherapy	Complete clinical response	Locoregional recurrence
Nakagawa et al[41]	52	No	45-50.4 Gy, 28 fractions, 38 d	Fluorouracil + leucovorin	10 (19.2)	8 (80)
Habr-Gama et al[42]	360	Yes (14%)	50.4 Gy, 28 fractions, 5-6 wk	Fluorouracil + leucovorin	99 (27.5)	6 (6)
Lim et al[43]	48	T1/t2 (33%)	Mean 50 Gy, 25 fractions	Fluorouracil	27 (56)	11 (23)
Hughes et al[44]	58	No	45 Gy, 25 fractions, 33 d	Fluorouracil + leucovorin	10 (17)	6 (60)
Dalton et al[45]	49	No	45 Gy, 25 fractions, 33 d	Capecitabine	12 (24)	6 (50)
Maas et al[46]	192	Yes (24%)	50.4 Gy, 28 fractions, 6 wk	Capecitabine	21 (10.9)	1 (5)