Fecal immunochemical test accuracy in average-risk colorectal cancer screening

Table 3 Number of colonoscopies needed to detect one lesion and cost per lesion (€) according to positivity threshold and fecal immunochemical test testing strategy

Lesion	Positivity threshold (ng/mL)	No. need to scope		Cost per lesion detected (€)		Cost increment (€)
		FIT1	FITmax	FIT1	FITmax
CRC	0	155.80		16898
	50	13.40	20.20	2206	3489	58.16
	75	12.20	17.80	2038	3223	58.15
	100	11.00	16.40	1912	3055	59.78
	115	10.20	15.80	1814	2985	64.55
	150	12.00	17.50	2163	3451	59.55
	200	11.25	14.75	2075	3083	48.58
Advanced neoplasia1	0	8.20		889
	50	1.97	2.46	317	425	34.07
	75	1.91	2.28	312	413	32.37
	100	1.77	2.28	302	424	40.40
	115	1.76	2.26	306	426	39.22
	150	1.78	2.26	312	445	42.63
	200	1.67	2.19	311	456	46.62

¹Advanced neoplasia: advanced adenomas (adenoma > 1 cm in size with high-grade dysplasia or with villous component > 25) or colorectal cancer. FIT: Fecal immunochemical test; CRC: Colorectal cancer.