Fecal immunochemical test accuracy in average-risk colorectal cancer screening

doi:10.3748/wjg.v20.i4.1038

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2014; 20(4): 1038-1047
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1038

Table 1 Performance characteristics of fecal immunochemical test-1 and -max for colorectal cancer detection at different positive thresholds n (%)

Hemoglobin concentration (ng/mL)	FIT strategy	Individuals with a positive result¹	Sensitivity²	Specificity²	Positive predictive value²	Negative predictive value²	Positive likelihood ratio²	Negative likelihood ratio²
50	FIT1³	67 (8.6)	100 (90-100)	92 (90-94)	7 (0-15)	100 (100-100)	12.48 (9.83-15.85)	-
50	FITmax⁴	101 (13.0)	100 (90-100)	88.60 (85-90)	5 (0-10)	100 (100-100)	8.06 (6.69-9.72)	-
75	FIT1³	61 (7.8)	100 (90-100)	93 (91-95)	8 (0-16)	100 (100-100)	13.82 (10.74-17)	-
75	FITmax⁴	89 (11.4)	100 (90-100)	89 (87-91)	6 (0-11)	100 (100-100)	9.21 (7.53-11.28)	-
100	FIT1³	55 (7.1)	100 (90-100)	94 (92-95)	9 (1-18)	100 (100-100)	15.48 (11.84-20.24)	-
100	FITmax⁴	82 (10.5)	100 (90-100)	90 (88-92)	6 (0-12)	100 (100-100)	10.05 (8.13-12.43)	-
115	FIT1³	51 (6.5)	100 (90-100)	94 (92-96)	10 (1-19)	100 (100-100)	16.83 (12.71-22.7)	-
115	FITmax⁴	79 (10.1)	100 (90-100)	90 (88-93)	6 (0-12)	100 (100-100)	10.46 (8.42-12.99)	-
150	FIT1³	48 (6.2)	80 (35-100)	94 (93-96)	8 (0-17)	100 (100-100)	14.07 (8.33-23.76)	0.21 (0.04-1.22)
150	FITmax⁴	70 (9.0)	80 (35-100)	91 (89-94)	6 (0-12)	100 (100-100)	9.38 (5.72-15.40)	0.22 (0.04-1.26)
200	FIT1³	45 (5.8)	80 (35-100)	95 (93-96)	9 (0-18)	100 (100-100)	15.10 (8.89-25.66)	0.21 (0.04-1.22)
200	FITmax⁴	59 (7.6)	80 (35-100)	93 (91-95)	7 (0-14)	100 (100-100)	11.26 (6.78-18.69)	0.22 (0.04-1.24)

¹Values are expressed as absolute numbers and percentage;

²Values are expressed as percentage and its 95%CI;

³Fecal hemoglobin concentration in the first sample;

⁴Higher fecal hemoglobin concentration of the two samples. FIT: Fecal immunochemical test.

Citation: Hernandez V, Cubiella J, Gonzalez-Mao MC, Iglesias F, Rivera C, Iglesias MB, Cid L, Castro I, Castro L, Vega P, Hermo JA, Macenlle R, Martínez-Turnes A, Martínez-Ares D, Estevez P, Cid E, Vidal MC, López-Martínez A, Hijona E, Herreros-Villanueva M, Bujanda L, investigators JIRPTCS. Fecal immunochemical test accuracy in average-risk colorectal cancer screening. World J Gastroenterol 2014; 20(4): 1038-1047
URL: https://www.wjgnet.com/1007-9327/full/v20/i4/1038.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i4.1038