FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

Figure 3 GW4064 reduces hepatic proinflammatory cytokine expression in a murine nonalcoholic fatty liver disease model. RNA was extracted from the liver tissues of normal diet, high-fat (HF), HF + lipopolysaccharide (LPS), and HF + GW4064 + LPS mice. Real-time polymerase chain reaction was used to determine the mRNA levels of Tnf, Mcp1, Il1b, Il6, Il17, and Ifng. ^aP < 0.05, ^bP < 0.01 vs HF + LPS group.