FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

Figure 2 GW4064 reduces apoptosis and macrophage infiltration in a murine nonalcoholic fatty liver disease model. A: Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining of liver sections (magnification × 400) from normal diet, high-fat (HF), HF + lipopolysaccharide (LPS), and HF + GW4064 + LPS mice; B: Quantification of TUNEL in each high power field (HPF); C: Representative immunohistochemical staining of F4/80 in the livers (magnification × 400) of normal diet, HF, HF + LPS, and HF + GW4064 + LPS mice; D: Quantification of F4/80-positive cells in each HPF. ^aP < 0.05, ^bP < 0.01 vs HF + LPS group.