Gene expression profile of peripheral blood in colorectal cancer

Table 7 Logistic regression models for 12 pooled microarray data sets as the external validation of colorectal cancer -associated genes from three studies

	Model 1			Model 2			Model 3
	B	S.E.	P value	B	S.E.	P value	B	S.E.	P value
Five selected genes of this study:
MDM2	6.069	1.461	< 0.001
DUSP6	1.360	0.235	< 0.001
CPEB4	-3.177	0.383	< 0.001
MMD	0.335	0.442	0.448
EIF2S3	1.462	0.244	< 0.001
Seven selected genes of Marshall et al[14]
ANXA3				0.559	0.212	0.008
CLEC4D				46.259	9.918	< 0.001
LMNB1				1.883	0.330	< 0.001
PRRG4				-1.284	0.371	0.001
TNFAIP6				1.787	0.377	< 0.001
VNN1				0.207	0.159	0.194
IL2RB				0.269	0.216	0.213
Five selected genes of Han et al[15]
CDA							-0.496	0.090	< 0.001
MGC20553							-1.386	0.197	< 0.001
BANK1							0.565	0.373	0.129
BCNP1							-0.944	1.148	0.411
MS4A1							-1.483	0.457	0.001
Constant	-32.758	6.001	< 0.001	-124.678	25.437	< 0.001	16.601	2.995	< 0.001
H-L		0.460			0.044			0.194
R2		0.853			0.841			0.693
AUC		0.978			0.985			0.957
Accuracy		0.949			0.974			0.939
Specificity		0.818			0.886			0.716
Sensitivity		0.971			0.988			0.977

Model 1: Five selected genes of this study; Model 2: Seven selected genes of Marshall et al[14]; Model 3: Five selected genes of Han et al[15]; B: Logistic regression coefficient beta; SE: Standard error of B; P: P value with statistical significance; H-L: Hosmer and Lemeshow test P value R2: Nagelkerke R Square; AUC: Area under ROC.