Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor

Figure 2 Pathologic findings of surgically removed tissue. A: High-power view of the tumor shows medium to large sized tumor cells with scanty cytoplasm, prominent nucleoli, and coarse “salt and pepper” chromatin. The tumor cells exhibited intense mitosis greater than 10/10 HPF (HE × 400); B-D: Immunohistochemically, tumor cells showed a diffuse and strong membranous positivity for CD56 (B), as well as cytoplasmic positivity for chromogranin (C) and synaptophysin (D) (immunohistochemical staining × 400).