Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients

Figure 3 Nonsteroidal anti-inflammatory drugs-induced acute hepatitis. A: There is a bridging necrosis zone around the central vein (HE, × 100); B: Vacuole and necrosis are found in hepatic cells around the necrosis zone (HE, × 400); C: A substantial inflammatory cells including lymphocytes, plasma cells, and eosinophils infiltrate can be seen in the portal tract (HE, × 400); D: Hepatic necrosis and lymphocytic infiltration, including some eosinophils (arrow), in the collapsed parenchyma can be observed (HE, × 400); E: NSAID-induced acute cholestasis; E: Small bile duct dilation and cholestasis can be seen in the portal area (HE, × 400); F: The cholestasis accompanying hepatocellular vacuolation is presented (HE, × 100). HE: Hematoxylin and eosin staining; NSAID: Nonsteroidal anti-inflammatory drug.