Rho/ROCK signaling in motility and metastasis of gastric cancer

Figure 3 Cancer cells display two different modes of cell motility: epithelial-mesenchymal transition and amoeboid transition. A: cells move in groups through the extracellular matrix and maintain cell–cell adhesions in sheet-like structures; B: Mesenchymal movement requires degradation of the extracellular matrix (ECM), similar to collective movement; C: Cells with amoeboid movement migrate in an integrin-independent manner.