Accuracy of early detection of colorectal tumours by stool methylation markers: A meta-analysis

doi:10.3748/wjg.v20.i38.14040

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastroenterol. Oct 14, 2014; 20(38): 14040-14050
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.14040

Table 4 Weighted meta-regression on the diagnostic accuracy of the methylation of genes assays

Covariates	Coefficient	SE	P value	RDOR	95%CI
QUADAS score¹	0.062	0.413	0.881	1.06	(0.46-2.47)
Detection method²	-0.146	0.401	0.719	0.86	(0.38-1.96)
Blinded design³	-0.166	0.364	0.651	0.85	(0.40-1.78)
Methylation genes⁴	-0.036	0.444	0.936	0.96	(0.39-2.39)

¹QUADAS score, which was divided into studies with higher quality (QUADAS score ≥ 10) and those with lower quality (QUADAS score < 10);

²Detection method, which was divided into qualitative and quantitative assay methods;

³Blinded design: the study was included with or without blinded design;

⁴Methylation genes, which were divided into single gene and combination genes.

Citation: Zhang H, Qi J, Wu YQ, Zhang P, Jiang J, Wang QX, Zhu YQ. Accuracy of early detection of colorectal tumours by stool methylation markers: A meta-analysis. World J Gastroenterol 2014; 20(38): 14040-14050
URL: https://www.wjgnet.com/1007-9327/full/v20/i38/14040.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i38.14040