Apolipoprotein C3 (-455T>C) polymorphism confers susceptibility to nonalcoholic fatty liver disease in the Southern Han Chinese population

Table 1 Clinical characteristics between the control group and the nonalcoholic fatty liver disease group n (%)

Item	Control	NAFLD	P value	Frequency of disorders in NAFLD group
Gender (n)				--
Male	200	200	1.0	--
Female	100	100	1.0	--
Age (yr)	39.5 ± 9.1	40.7 ± 9.7	0.11	--
BMI (kg/m2)	22.1 ± 2.8	26.3 ± 4.2	< 0.001	186 (62.0)
Blood pressure (mmHg)	--	--	--	64 (21.3)
Systolic pressure	119 ± 13	127 ± 13	< 0.001	--
Diastolic pressure	75 ± 10	82 ± 9	< 0.001	--
HDL (mmol/L)	--	--	--	128 (42.7)
Male	1.4 ± 0.2	1.1 ± 0.2	< 0.001	107 (53.5)
Female	1.4 ± 0.2	1.3 ± 0.3	< 0.001	21 (21.0)
Total cholesterol (mmol/L)	4.7 ± 0.5	5.4 ± 1.0	< 0.001	122 (40.7)
TG (mmol/L)	1.0 ± 0.5	2.5 ± 2.5	< 0.001	119 (39.7)
UA (μmol/L)	--	--	--	104 (34.7)
Male	335.3 ± 51.2	415.5 ± 97.2	< 0.001	89 (44.5)
Female	241.3 ± 39.5	324.0 ± 83.6	< 0.001	15 (15.0)
LDL (mmol/L)	2.7 ± 0.5	3.3 ± 0.9	< 0.001	90 (30.0)
FPI (μU/mL)	6.0 ± 3.1	10.62 ± 4.5	< 0.001	--
HOMA-IR	1.2 ± 0.7	2.4 ± 1.2	< 0.001	74 (24.7)
FPG (mmol/L)	4.8 ± 0.5	5.3 ± 1.1	< 0.001	67 (22.3)
ALT (U/L)	19.0 ± 8.7	42.1 ± 32.6	< 0.001	114 (38.0)
AST (U/L)	24.1 ± 4.9	33.1 ± 14.8	< 0.001	148 (49.3)

NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index; HDL: High-density lipoprotein cholesterol; TG: Triglyceride; UA: Uric acid; LDL: Low-density lipoprotein cholesterol; FPI: Fasting plasma insulin; HOMA-IR: Homeostasis model of assessment for insulin resistance index; FPG: Fasting plasma glucose; ALT: Alanine aminotranferase; AST: Aspartate aminotransferase.