Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients

Table 5 Histology and outcome of non-steroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity

No.	Sex/Age	Immunofluorescent staining	Renal lesion	Liver lesion	Treatment and outcome
1	M/64	IgM++, IgA±, C3±	Acute tubulointerstitial disease	Acute hepatitis	Steroid 0.5 mg/kg, tappered to zero in 3 mo, ALT normalized in day 33, Scr normalized in day 182
2	M/71	Negative	Acute interstitial nephritis	Acute hepatitis	Anti-hepatitis B virus, steroid 0.5 mg/kg, tappered to zero in 3 mo, ALT normalized in day 50, Scr normalized in day 60
3	M/69	IgM±, IgA±, C3±	Acute tubulointerstitial disease	Acute hepatitis	Steroid 1 mg/kg, tappered to zero in 6 mo, cyclophosphamide accumulated to 6 g, potassium supplement, correction of acidosis, ALT normalized in day 40, Renal tubular acidosis normalized in day 15, Scr 140 μmol/L (10/8/2013)
4	F/53	IgA2+, C3+	Focal proliferative IgA nephropathy associated with acute tubulointerstitial nephropathy	Acute hepatitis	Steroid 1 mg/kg, tappered to 10 mg/d in 1 yr, cyclophosphamide accumulated to 6 g, ALT normalized in day 46, Scr 154 μmol/L (11/16/2013)
5	F/68	IgM+, C3±	Acute interstitial nephritis	ND	Steroid 0.5 mg/kg, tappered to zero in 3 mo, ALT normalized in day 145, Scr normalized in day 12.
6	F/37	Negative	Acute interstitial nephritis	Acute cholestasis	symptomatic treatment, Scr normalized in day 35, ALT normalized in day 86
7	F/17	ND	ND	Chronic cholestatic hepatitis (during transplantation)	Symptomatic treatment, Scr normalized in day 205, liver transplantation

F: Female; M: Male; ND: Not-done; ALI: Acute liver injury.