Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients

Table 2 Clinical characteristics of non-steroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity

No.	Sex/Age	Serology of infections	History	NSAID: Dose and duration of use	Other drug concurrent used	Extracellular volume depletion	Peak creatinine	Peak ALT	Peak ALP	Peak bilirubin
1	M/64	HBcAb(+)	Diabetes’s mellitus, alcohol use	Tylenol 0.5 g × 5 pills, Ibuprofen 0.3 g for 2 d	Erythromycin, Telmisartan	Fever (40 °C) watery diarrhea for 2 d	6.7 mg/dL	2565 U/L	141 U/L	131.3 μmol/L
2	M/71	HBsAg(+)	Hypertension, alcohol use	Lysine acetylsalicylate 1.5 g × 2 pills, Nimesulide 0.1 g × 2 pills for 3 d	Cefoxitin, Fosinopril	Fever (39 °C-40 °C) for 3 d	5.3 mg/dL	8960 U/L	598 U/L	265.6 μmol/L
3	M/69	HBcAb(+)	Spondylolisthesis lumbar backaches, alcohol use	Celecoxib 25 mg/d, for 1 yr, Diclofenac Sodium 1/d, for 1 mo	Rhizoma Cibotii, Herba	No evidence	2.2 mg/dL	619 U/L	224 U/L	21.6 μmol/L
					Epimedii, Rhizoma Drynariae,
					Radix Aucklandiae, Caulis Spatholobui, Radix Dipsaci
4	F/53	HBcAb(+) HBeAb(+)	IgA nephropathy, Alcohol use for 20 yr	Indomethacin 75 mg × 2 pills for 2 d	Lotensin, Cefaclor	Fever (39 °C) for 2 d	7.6 mg/dL	1336 U/L	74 U/L	39.1 μmol/L
5	F/68	HBeAb(+)	Arthritis, hypertension, alcohol use	Rofecoxib 25 mg/d, for 1 mo	Irbesartan, Nifedipine, Herb including cinnabar and flower of silktree albizzia	Diarrhea for 3 d	3.9 mg/dL	1186 U/L	209 U/L	336.4 μmol/L
6	F/37	(-)	Polycystic ovary syndrome, dysmenorrhea	Piroxicam 40 mg/d for 10 d, Paracetamol, 0.1 × 35 pills intermittent for 3 mo	Herb for regulating the menstrual cycle, slimming herb	No evidence	2.1 mg/dL	105 U/L	488 U/L	214 μmol/L
7	F/17	HBsAb(+)	Chronic diarrhea for 1 yr, acute pancreatitis for 1 mo	Ibuprofen 0.3 g × 5 pills, Indomethacin 75 mg × 10 pills intermittent for 1 mo	Norfloxacin Baccidal, Rifampicin, Cefoperazone, Meropenem, Hepatoprotective herbs, Diflucan	Diarrhea, intermittent fever for 1 mo	5.6 mg/dL	1548 U/L	600 U/L	350 μmol/L

F: Female; M: Male; NSAID: Nonsteroidal anti-inflammatory drug; ALT: Alanine aminotransferase; ALP: Alanine aminotransferase; HBcAb: Hepatitis B core antibody; HBsAg: Hepatitis B surface antigen; HBeAb: Hepatitis B e antibody; HBsAb: Hepatitis B surface antibody.