Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers

Table 6 Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) with non-viral chronic liver diseases (n = 25)

	AUROC	95%CI	Pairwise comparison of ROC curves
			Factor	Difference between areas (95%CI)	P value
Significant fibrosis
SWE	0.979	0.826-0.988	HA	0.035 (-0.058-0.128)	0.465
			Type IV	0.035 (-0.051-0.121)	0.429
			APRI	0.389 (0.163-0.615)	0.001
HA	0.944	0.773-0.993	Type IV	0.000 (-0.103-0.103)	1.000
			APRI	0.354 (0.137-0.572)	0.001
Type IV	0.944	0.773-0.993	APRI	0.354 (0.130-0.578)	0.002
APRI	0.590	0.378-0.781
Advanced fibrosis
SWE	0.910	0.726-0.985	HA	0.077 (-0.042-0.196)	0.206
			Type IV	0.090 (-0.034-0.214)	0.156
			APRI	0.295 (0.060-0.530)	0.014
HA	0.987	0.839-1.000	Type IV	0.013 (-0.034-0.060)	0.593
			APRI	0.372 (0.155-0.589)	0.001
Type IV	1.000	0.862-1.000	APRI	0.385 (0.160-0.609)	0.001
APRI	0.615	0.401-0.801

ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.