Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers

Table 5 Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) in patients with chronic viral hepatitis (n =36)

	AUROC	95%CI	Pairwise comparison of ROC curves
			Factor	Difference between areas (95%CI)	P value
Significant fibrosis
SWE	0.935	0.800-0.989	HA	0.277 (0.070-0.485)	0.009
			Type IV	0.158 (-0.009-0.325)	0.063
			APRI	0.077 (-0.066-0.220)	0.289
HA	0.658	0.482-0.807	Type IV	0.119 (-0.084-0.326)	0.257
			APRI	0.200 (-0.029-0.429)	0.086
Type IV	0.777	0.608-0.898	APRI	0.081 (-0.126-0.288)	0.445
APRI	0.858	0.701-0.951
Advanced fibrosis
SWE	0.914	0.771-0.980	HA	0.094 (-0.054-0.243)	0.214
			Type IV	0.120 (-0.030-0.271)	0.118
			APRI	0.086 (-0.061-0.234)	0.250
HA	0.819	0.656-0.927	Type IV	0.026 (-0.120-0.172)	0.725
			APRI	0.008 (-0.168-0.183)	0.931
Type IV	0.793	0.626-0.909	APRI	0.034 (-0.153-0.221)	0.722
APRI	0.827	0.665-0.932

ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.