Current issues and future perspectives of gastric cancer screening

Table 3 Results of prediction based on a combination of Helicobacter pylori antibody and serum pepsinogen screening

	Ohata et al[38]	Watabe et al[40]	Mizuno et al[39]
Basic characteristics
Year published	2004	2005	2009
Location	Wakayama	Chiba	Kyoto
Total number	4655	6983	2859
Men/Women	4655/0	3320/2260	1011/1848
Age	48.3 (average)	48.9 (average)	≥ 35
Follow-up (yr)	7.7 (average)	4.7 (average)	10 (maximum)
HP positive rate (%)	78.6	46.1	75
PG positive rate (%)	28.9	21.8	39.2
Number of detected cancer	45	43	61
Incidence of gastric cancer (/1000)	9.67	6.16	21.3
HP-/PG-
Total number	967	3324	647
Number of detected cancer	0	7	2
Incidence of gastric cancer (/1000)	-	2.11	3.09
HP+/PG-
Total number	2341	2134	1094
Number of detected cancer	19	6	15
Incidence of gastric cancer (/1000)	8.12	2.81	13.71
HP+/PG+
Total number	1316	1082	1054
Number of detected cancer	24	18	41
Incidence of gastric cancer (/1000)	18.24	16.64	38.9
HP-/PG+
Total number	31	443	69
Number of detected cancer	2	12	3
Incidence of gastric cancer (/1000)	64.52	27.09	43.48

HP: Helicobacter pylori antibody; PG: Serum pepsinogen.