Molecular targeting to treat gastric cancer

doi:10.3748/wjg.v20.i38.13741

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Oct 14, 2014 (publication date) through Jul 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2014; 20(38): 13741-13755
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13741

Table 7 Clinical trials of cetuximab and panitumumab

Patients	Phase	Treatment	n	OS (m)	PFS (m)	RR	DCR
Previously untreated advanced gastric cancer (EXPAND)	III	Capecitabine + cisplatin	449	10.7	5.6	29%	71%
Previously untreated advanced gastric cancer (EXPAND)	III	Capecitabine + cisplatin + cetuximab	455	9.4	4.4	30%	73%
Untreated metastatic or locally advanced oesophagogastric adenocarcinoma (REAL 3)	III	EOC (epirubicin + oxaliplatin + capecitabine)	275	11.3	6.0	42%	63%
	III	Modified dose EOC + panitumumab	278	8.8	7.4	46%	64%

DCR: Disease control rate; N/A: Not available; OS: Overall survival; PFS: Progression-free-survival; RR: Response rate.

Citation: Aoyagi K, Kouhuji K, Kizaki J, Isobe T, Hashimoto K, Shirouzu K. Molecular targeting to treat gastric cancer. World J Gastroenterol 2014; 20(38): 13741-13755
URL: https://www.wjgnet.com/1007-9327/full/v20/i38/13741.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i38.13741