Molecular targeting to treat gastric cancer

doi:10.3748/wjg.v20.i38.13741

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Oct 14, 2014 (publication date) through Feb 5, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2014; 20(38): 13741-13755
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13741

Table 2 Clinical trials of sunitinib

Patients	Phase	Treatment	n	OS (m)	PFS (m)	TTP (m)	RR	DCR
Pretreated patients with advanced gastric cancer	II	Sunitinib	51	5.8	1.28	N/A	3.9%	20.0%
Second line treatment for advanced gastric cancer	II	Sunitinib	78	6.8	2.3	2.3	2.6%	34.7%
Unresectable or metastatic advanced gastric cancer after failed treatment with fluoropyrimidine + platinum	II	Docetaxel	49	6.6	N/A	2.6	14.3%	51.0%
	II	Docetaxel + sunitinib	56	8.0	N/A	3.9	41.1%	75.0%

DCR: Disease control rate; N/A: Not available; OS: Overall survival; PFS: Progression-free-survival; RR: Response rate; TTP: Time to progression.

Citation: Aoyagi K, Kouhuji K, Kizaki J, Isobe T, Hashimoto K, Shirouzu K. Molecular targeting to treat gastric cancer. World J Gastroenterol 2014; 20(38): 13741-13755
URL: https://www.wjgnet.com/1007-9327/full/v20/i38/13741.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i38.13741