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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 14, 2014; 20(38): 13637-13647
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13637
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13637
Table 2 Major phase III trials for gastric cancer in the advanced setting
Trial | n | Treatment arms | HR for overall survival (P value) | Survival comparison |
Advanced gastric cancer - first-line | ||||
Bang et al[39] | 584 | CX, CF and trastuzumab vs CX and CF1 | 0.74 (0.0046) | Overall survival: 13.8 mo vs 11.1 mo |
Ohtsu et al[42] | 774 | Cisplatin and 5-FU vs cisplatin, 5-FU and bevacizumab | 0.87 (0.1002) | Overall survival: 10.1 mo vs 12.1 mo |
PFS: 5.3 mo vs 6.7 mo | ||||
Lordick et al[44] | 904 | CX vs CX and cetuximab | 1.004 (0.9547) | Overall survival: 10.7 mo vs 9.4 mo |
Waddell et al[45] | 553 | EOC vs mEOC–P | 1.37 (0.013) | Overall survival: 11.3 mo vs 8.8 mo |
Van Cutsem et al[37] | 445 | DCF vs CF | TTP 1.47 (< 0.001) OS 1.29 (0.02) | Time to progression: 5.6 mo vs 3.7 mo, 9.2 mo vs 8.6 mo |
Koizumi et al[40] | 305 | S-1 and cisplatin vs S-1 | 0.77 (0.04) | Overall survival: 13.0 mo vs 11.0 mo |
Ajani et al[66] | 1053 | Cisplatin and S-1 vs cisplatin and 5-FU | 0.92 (0.20) | Overall survival: 8.6 mo vs 7.9 mo |
Hecht et al[67] | 545 | CapeOx and lapatinib vs CapeOx and placebo | 0.91 (0.35) | Overall survival: 12.2 mo vs 10.5 mo |
Advanced gastric cancer - second-line | ||||
Ohtsu et al[51] | 656 | BSC and placebo vs BSC and everolimus | 0.90 (0.1244) | Overall survival: 4.3 mo vs 5.4 mo |
Fuchs et al[47] | 355 | BSC and ramucirumab vs BSC | 0.776 (0.047) | Overall survival: 5.2 mo vs 3.8 mo |
Bang et al[52] | 261 | Lapatinib and paclitaxel vs paclitaxel | 0.84 (0.2088) | Overall survival: 11.0 mo vs 8.9 mo |
Kang et al[50] | 202 | BSC vs docetaxel or irinotecan | 0.657 (0.007) | Overall survival: 3.8 mo vs 5.3 mo |
Thuss-Patience et al[48] | 40 | Irinotecan and BSC vs BSC | 0.48 (0.012) | Overall survival: 4.0 mo vs 2.4 mo |
Cook et al[49] | 168 | Docetaxel and ASC vs ASC | 0.67 (0.01) | Overall survival: 5.2 mo vs 3.6 mo |
- Citation: Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA. Medical management of gastric cancer: A 2014 update. World J Gastroenterol 2014; 20(38): 13637-13647
- URL: https://www.wjgnet.com/1007-9327/full/v20/i38/13637.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i38.13637