Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer: Where are we now in the era of the next generation proteomics?

Figure 2 Potential proteomic markers signifying colitis-associated cancer risks in inflammatory bowel disease. A: Proteomic markers for colitis-associated cancer (CAC) risk in patients with ulcerative colitis (UC). The analysis was performed according to the degree of intestinal inflammation, type of inflammatory bowel disease and extent of inflammation. Compared with the analysis of CAC, 22 significant potential biomarkers of CAC risk were obtained from patients as p with UC, six biomarkers existing in the extracellular space, two biomarkers at the plasma membrane, seven are from the cytoplasm, and seven are nuclear proteins; B: Proteomic markers for CAC risk in patients with Crohn’s disease (CD). Eighteen potential biomarkers for the risk of CAC were identified in patients with CD. Four were from the plasma membrane, 11 from the cytoplasm, and three from the nucleus.