Study of liver cirrhosis over ten consecutive years in Southern China

Table 5 Etiologic analysis for the years 2001-2005 and the years 2006-2010 n (%)

Etiology	2001-2005 (n = 2907)	2006-2010 (n = 5173)	χ2-value	P value	P-trend
Viral hepatitis	2462 (84.7)	4052 (78.3)	48.22	< 0.001	< 0.001
HBV	2381 (81.9)	3858 (74.6)	56.78	< 0.001	< 0.001
HCV	67 (2.3)	159 (3.1)	4.05	0.044	0.263
HBV + HCV	12 (0.4)	35 (0.7)	2.24	0.135	0.267
HBV + HDV	2 (0.1)	0 (0.0)	-	0.129	-
Alcohol	155 (5.3)	304 (5.9)	1.031	0.31	0.919
Autoimmune	34 (1.2)	129 (2.5)	16.509	< 0.001	< 0.001
Secondary biliary	12 (0.4)	26 (0.5)	0.321	0.571	0.369
Metabolic diseases	32 (1.1)	82 (1.6)	3.139	0.076	0.07
Drugs	1 (0.0)	8 (0.2)	1.459	0.227	0.161
Vascular diseases	17 (0.6)	29 (0.6)	0.019	0.89	0.551
Parasites	14 (0.5)	19 (0.4)	0.598	0.439	0.154
IHS	2 (0.1)	6 (0.1)	0.078	0.78	0.696
Mixed etiology	87 (3.0)	313 (6.1)	36.984	< 0.001	< 0.001
Other known etiology	16 (0.5)	43 (0.8)	2.95	0.086	0.285
Cryptogenic cirrhosis	75 (2.6)	162 (3.1)	1.989	0.158	0.011

The P values were determined using the χ² test by comparing the proportion of 2001-2005 with that of 2006-2010. The P-trend values were determined using ANOVA by comparing proportions of separated years and reflected the general trend of the etiology proportion in the 10 consecutive years.