Study of liver cirrhosis over ten consecutive years in Southern China

Table 3 Etiology of the 8080 enrolled liver cirrhosis patients n (%)

Etiology	Total	Male	Female	P value
	(n = 8080)	(n = 6719)	(n = 1361)
Viral hepatitis	6514 (80.62)	5489 (81.69)	1025 (75.31)	< 0.001
HBV	6239 (77.22)	5316 (79.12)	923 (67.82)
HCV	226 (2.80)	135 (2.01)	91 (6.69)
HBV + HDV	2 (0.02)	2 (0.03)	0 (0.00)
HBV + HCV	47 (0.58)	36 (0.54)	11 (0.81)
Alcohol	459 (5.68)	451 (6.71)	8 (0.59)	< 0.001
Autoimmune	163 (2.03)	30 (0.43)	133 (9.77)	< 0.001
AIH	54 (0.67)	13 (0.19)	41 (3.01)
PBC	87 (1.08)	15 (0.22)	72 (5.29)
AIH + PBC	19 (0.24)	1 (0.01)	18 (1.32)
PSC	3 (0.04)	1 (0.01)	2 (0.15)
Secondary biliary	38 (0.47)	22 (0.33)	16 (1.18)	< 0.001
Metabolic diseases	114 (1.40)	73 (1.09)	41 (3.02)	< 0.001
WD	106 (1.31)	67 (1.00)	39 (2.87)
HH	2 (0.02)	2 (0.03)	0 (0.00)
NAFLD	4 (0.05)	2 (0.03)	2 (0.15)
Others	2 (0.02)	2 (0.03)	0 (0.00)
Drugs	9 (0.11)	6 (0.09)	3 (0.22)	0.186
Vascular diseases	46 (0.57)	30 (0.44)	16 (1.17)	0.001
BCS	31 (0.38)	21 (0.31)	10 (0.73)
Cardiac	15 (0.19)	9 (0.13)	6 (0.44)
Parasites	33 (0.41)	26 (0.39)	7 (0.51)	0.502
IHS	8 (0.10)	7 (0.10)	1 (0.07)	1.000
Mixed etiology	400 (4.95)	399 (5.93)	1 (0.07)	< 0.001
HBV + Alcohol	389 (4.81)	388 (5.77)	1 (0.07)
HBV + HCV + Alcohol	11 (0.14)	11 (0.16)	0 (0.00)
Other known etiology	59 (0.73)	51 (0.76)	8 (0.58)	0.499
Cryptogenic cirrhosis	237 (2.93)	135 (2.01)	102 (7.49)	< 0.001

The differences in gender proportion were determined using the χ² test. HBV: Hepatitis B virus; HCV: Hepatitis C virus; HDV: Hepatitis D virus; AIH: Autoimmune hepatitis; PBC: Primary biliary cirrhosis; PSC: Primary sclerosing cholangitis; WD: Wilson’s disease; HH: Hereditary hemochromatosis; NAFLD: Non-alcoholic fatty liver disease; BCS: Budd-Chiari syndrome; IHS: Infantile hepatitis syndrome.