Review of experimental attempts of islet allotransplantation in rodents: Parameters involved and viability of the procedure

Table 5 Quantitative analysis of immunosuppressant drugs use

Ref.	Immunosuppression	Dose	Administration frequency
Fotiadis et al[9]	MMF and CsA	12 mg/kg and 23 mg/kg (MMF) 5 mg/kg (CsA)	-
Merani et al[10]	AEB-071 (Protein Kinase C Inhibitory) + CsA, CTLA4-Ig, MMF	30 mg/kg (AEB-071) 2.5 mg/kg and 5 mg/kg (CsA) 0.25 mg (CTLA4-Ig Intraperitoneal) 10 mg/kg (MMF)	2 times a day, oral (AEB-071) 2 times a day, oral (CsA) 0, 2, 4 and 6 PO, Intraperitoneal (CTLA4-Ig) Once a day, oral (MMF)
Nishimura et al[11]	Tacrolimus	0.5 mg/kg	Infused subcutaneously - Daily - for 14 d
Makhlouf et al[12]	Blockade of CD28:B7 and anti-CD40 L; CTLA-4	250μg	Intraperitoneal - 0, 2, 4 and 6 PO
Wee et al[14]	CsA+Tautomycetin (Synergist)	5 mg/g and 15 mg/kg (CsA)	Once a day for 7 d
Watanabe et al[16]	Tacrolimus and DHMEQ	1.5 mg/kg (Tacrolimus) 20 mg/kg (DHMEQ)	Once a day 0 to 3 PO and 2 times a day 0 to 14 PO (DHMEQ); 0 to 14 PO (Tacrolimus); Once a day 0 to 3 PO (DHMEQ)+0 to 14 PO (Tacrolimus)
Xekouki et al[18]	CsA and MMF1	5 mg/kg (CsA) 12 mg/kg (MMF) 23 mg/kg (MMF)	Oral - Daily - 12 consecutive days
Baker et al[19]	Monoclonal antibody antiBIP-10	300 μg intraperitoneal	Daily - 14 d1
Vieiro et al[21]	Tritiated thymidine (preoperative) and CsA	20 mg/kg (CsA)	N/A
Melzi et al[23]	Rapamycin + FK506 + anti–IL-2Ra chain mAbs and rapamycin+IL-10	1 mg/kg (Rapamycin) 0.05 μg/kg (IL-10) 0.3 mg/kg (FK506) 1 mg/kg (mAbs)	Intraperitoneal: Once a day - 30 PO (Rapamycin) 2 times a day - 30 d (IL-10) Once a day - 30 d (FK506) 0.4 PO (mAbs)
Fan et al[25]	LTβ R-Ig, CTLA4-Ig or LTR mAb anti mouse	200 μg	Intraperitoneal- days -1, 1, 3, 5, 7 and 9
Jung et al[26]	CD154 mAb (MR1) anti mouse + ROS-A	250 μg (CD154 mAb (MR1) anti mouse) 200 mg/kg of Ros A	Intraperitoneal injection 0, 2, 4, 6 and 8 PO (CD154 mAb (MR1) anti mouse) 8 consecutive days (ROS-A)
Påhlman et al[27]	AR-C117977 or CsA	0.2 mL - 3, 10, 30, or 100 mg/kg (AR-C117977) 0.5 mL - 20 mg/kg (CsA)	Subcutaneous - once a day 0 to 9 PO (AR-C117977) Once a day 0-9 PO or 0-39 PO (CsA)
Wang et al[28]	B7-H4	5 plaque-forming units (pfu) of Ad-B7-H4 or Ad-LacZ	N/A
Potiron et al[32]	CTLA4 Ig or CD40 Ig	5 109 IP of AdCTLA4 IM and/or 5 109 IM or 2 109 IV of AdCD40Ig; IM administration: 10 μL per point (3 points) IV administration: 150 μL with 0.9% sodium chloride	IM administration - anterior tibialis muscle; IV administration - venile vein
Jahr et al[33]	Anti-rat antilymphocyte serum	Intraperitoneal administration 0.5 mL	1 d after islet transplantation

¹First dose administered 4 h preoperatively. N/A: Not available; MMF: Mycophenolate mofetil; CsA: Cyclosporine A.