Gene therapy in pancreatic cancer

doi:10.3748/wjg.v20.i37.13343

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Oct 7, 2014 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 7, 2014; 20(37): 13343-13368
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13343

Table 6 Ongoing clinical trials of gene therapy in pancreatic cancer

Phase	Transgenes
I	Oncolytic adenovirus and oncolytic herpesvirus¹
	Somatostatin receptor 2 (sst2), Deoxycitidine kinase :: uridylmonophosphate kinase (dck::umk)
	Somatostatin receptor 2 (sst2)
	Mesothelin-scFv with signaling domains comprised of TCR , CD28, and 4-1BB (CD137) cDNA
	GM-CSF
	PANVAC (CEA, MUC-1, and TRICOM)
	Cytosine deaminase, Herpes simplex virus thymidine kinase (HSV-TK)
	Cyclin G1
	p53
	BikDD (DOTAP-cholesterol mediated gene transfection)
	Mutated Ras
I/II	Cytochrome p450
	AEG 35156: antisense oligonucleotide to X-linked inhibitor of apoptosis protein (XIAP)
	Herpes simplex virus thymidine kinase (HSV-TK)
	Diphtheria Toxin A Chain (DTA) gene with H19 promoter
	Alpha-(1,3) galactosyltransferase
II	CEA, MUC-1, and PANVAC
	Mutated Ras
	Alpha-(1,3) galactosyltransferase
III	Alpha-(1,3) galactosyltransferase
	PANVAC (CEA, MUC-1, and TRICOM)²

¹Clinical trials of oncolytic viruses were completed or are ongoing in Spain and Japan, and their details were not clear;

²This clinical trial has closed, but details and results have not been published yet.

Citation: Liu SX, Xia ZS, Zhong YQ. Gene therapy in pancreatic cancer. World J Gastroenterol 2014; 20(37): 13343-13368
URL: https://www.wjgnet.com/1007-9327/full/v20/i37/13343.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i37.13343