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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 7, 2014; 20(37): 13284-13292
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13284
Table 3 Summary of the long-term follow-up studies of interferon α treatment on the development of hepatitis B virus-related hepatocellular carcinoma
Ref.Study typeNumber of patients (treated/controls)Region of originHBeAg-positive (%)Cirrhosis (%)Treatment follow-up (yr)HCC development (% treated vs % controls)Significance(P value)
Lin et al[19]Prospective, randomized, controlled101 (67/34)Taiwan10012.57.41.5 vs 11.80.043
Lin et al[42]Retrospective, matched controls466 (233/233)Taiwan1009.46.82.7 vs 12.50.011
Ikeda et al[49]Retrospective, unmatched controls313 (94/219)Japan361006.917.0 vs 30.80.012
Krogsgaard et al[43]Retrospective, multicenter controlled trials308 (210/98)Europe1006.14.70.96 vs 1.0NS
International IFN-α HCC Study Group[50]Retrospective, multicenter, matched controls146 (49/97)Italy, ArgentinaNA916.516 vs 19NS
Mazzella et al[51]Prospective, randomized, controlled64 (33/ 31)Italy006.93.0 vs 6.4NS
Tangkijvanich et al[44]Retrospective, unmatched controls139 (69/72)Thailand10020.15.04.7 vs 12.5NS
Papatheodoridis et al[45]Retrospective, unmatched controls404 (209/195)Greece10030.96.08.1 vs 7.7NS
Truong et al[46]Retrospective, matched controls62 (27/35)Japan59.61.66.53.7 vs 0.0NS
Yuen et al[47]Prospective, matched controls411 (208/203)Hong Kong100NA8.92.4 vs 0.0NS
Number of analyzed studiesRD/RR95%CISignificance (P value)
Cammà et al[52]Meta-analysis853/6527 StudiesRD = -6.4% (overall)-2.8%-(-10%)< 0.001
RD = -4.8% (European)-11.1%-1.5%NS
Miyake et al[53]Meta-analysis553/7508 StudiesRD = -5.0% (overall)-9.4%-(-0.5%)0.028
RD = -8.5% (Asian)-13.6-(-3.6%)0.001
Sung et al[54]Meta-analysis1292/145812 StudiesRR = 0.660.48-0.890.006
Yang et al[55]Meta-analysis1006/107611 StudiesRR = 0.590.43-0.810.001
Zhang et al[56]Meta-analysis176/1712 StudiesRR = 0.230.05-1.04NS
Jin et al[57]Meta-analysis1291/10489 StudiesRR = 0.2740.059-1.031NS