Impact of proteolytic enzymes in colorectal cancer development and progression

Table 2 General roles of proteolytic enzymes in cancers

Degradation or disruption of basement membrane and extracellular matrix

Produce components which allow the in situ cancer cells to disseminate to distant organ

Formation of a complex microenvironment that promotes malignant transformation

Activation of growth factors, adhesion molecules

Suppression of tumor cell apoptosis

Destruction of chemokine gradients

Modulation of antitumor immune reactions

Dual and complex role in angiogenesis