Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis

Figure 3 Immunostaining for cyclooxygenase-2 in the gastric mucosa with chronic superficial gastritis (A), gastric glandular atrophy (B), intestinal metaplasia (C), dysplasia (D) and gastric cancer (E). Chronic superficial gastritis shows strong expression in foveolar and glandular epithelium and weak expression in mononuclear inflammatory cells, myofibroblasts, and endothelial cells in the lamina propria; gastric glandular atrophy shows strong expression in the atrophic glands of the gastric mucosa; intestinal metaplasia shows strong expression in intestinal epithelium and goblet cells; and gastric cancer shows strong expression in cancer cells. Reproduced from Ref [21].